Oral graft vs host disease: An immune system disorder in hematopoietic cell transplantation

Oral graft vs host disease: An immune system disorder in hematopoietic cell transplantation

World J Stomatol. May 20, 2015; 4(2): 96-102
Published online May 20, 2015. doi: 10.5321/wjs.v4.i2.96

Paulo Sérgio da Silva Santos, Cassia Maria Fischer Rubira, Héliton Spíndola Antunes, Fabio Luiz Coracin, Cristiane Miranda França

Graft vs host disease (GVHD) is a complication of patients who are treated by hematopoietic cell transplantation. National Institutes of Health in 2005 by Working Group on Diagnosis and Staging Consensus Development Project on Criteria for Clinical Trials in Chronic GVHD (cGVHD) established 2 principal categories of oral GVHD, acute and chronic. The oral mucosa may be the first site of manifestation of the disease. Clinical diagnosis needs to be confirmed by a biopsy of oral mucosa and minor salivary glands. Microscopic results have played a major role in the diagnosis and management of acute and chronic oral GVHD. Development of second malignancies is the greatest risk of oral cGVHD patients, mostly regarding squamous cell carcinoma. The focus of oral GVHD therapy is to improve symptoms and maintain oral function. The aim of this review article is to update the information on the oral GVHD in its clinical, microscopic features and their complications.

acesso ao artigo: http://www.wjgnet.com/2218-6263/abstract/v4/i2/96.htm